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Catalog Number
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GTX65287
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0
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Product Name
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GDF5 recombinant protein
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| Full Name | growth differentiation factor 5 |
| Synonyms | GDF5, Growth differentiation factor 5, CDMP1, Radotermin, Growth differentiation factor5, Cartilage-derived morphogenetic protein-1, LAP4, CDMP-1, Cartilagederived morphogenetic protein1, GDF-5, BMP-14, BMP14, SYNS2, GDF 5, CDMP 1, BMP 14 |
| Background | BMPs (bone morphogenetic proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. In addition to its osteogenic activity, BMP-14 is a principal inhibitor of cartilage development and is predominantly expressed in long bone during human embryonic development. Recombinant human BMP-14 is a 27 kDa homodimeric protein consisting of two 120 amino acid polypeptide chains. |
| Species | Human |
| Expression System | E. coli |
| Applications | Apuri, Blocking, ELISA, Functional Assay |
| Application Note | The ED50 as determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is 1-2 ug/ml. |
| Predicted Target Size(KDa) | 27 kDa(note) |
| Form Supplied | Lyophilized powder |
| Purification Note | Purity was assessed by SDS-PAGE (≥98%) and by HPLC (≥98%). |
| Storage Buffer | Sterile filtered and lyophilized from 10 mM Sodium Citrate, pH 3.5. |
| Storage Instruction | Store at -20 °C. Stable for 12 months from date of receipt.Reconstitute to a concentration of 0.1-1.0 mg/ml in water containing BSA (50 mg BSA per 1 mg of protein). This solution can then be diluted into other aqueous buffers. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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