BMPR1B antibody [N3C3]
|Applications||IHC-Fr, IHC-P, WB|
Not tested in other applications.
|IHC (Frozen sections)||1:100-1:1000*
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||57 kDa (note)
|Positive Controls||293T , Neuro2A , C8D30 , NIH-3T3 , human BMPR1B-transfected 293T , Rat2|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||bone morphogenetic protein receptor, type IB|
|Product Description||Rabbit polyclonal antibody to BMPR1B (bone morphogenetic protein receptor, type IB)|
|Background||This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. [provided by RefSeq]|
|Synonyms||ALK-6 antibody, ALK6 antibody, CDw293 antibody, BMPR1B antibody, BMPR-1B antibody, serine/threonine receptor kinase antibody, BMP type-1B receptor antibody, bone morphogenetic protein receptor type-1B antibody, activin receptor-like kinase 6 antibody, "bone morphogenetic protein receptor, type IB antibody"|
|Cellular Localization||Membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human BMPR1B. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat, Bovine|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Dog, Pig, Chicken, Sheep, Rhesus Monkey|
|Predict Reactivity Note||Dog (98%), Pig (98%), Chicken (96%), Sheep (98%), Rhesus Monkey (99%)|