|Full Name||bone morphogenetic protein receptor, type II (serine/threonine kinase)|
|Product Description||Rabbit polyclonal antibody to BMPR2 (bone morphogenetic protein receptor, type II (serine/threonine kinase))|
|Background||This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq]|
|Synonyms||BMPR-II antibody, BMPR3 antibody, BMR2 antibody, BRK-3 antibody, FLJ41585 antibody, FLJ76945 antibody, PPH1 antibody, T-ALK antibody, BMPR2 antibody, bone morphogenetic protein receptor type-2 antibody, bone morphogenetic protein receptor type II antibody, type II activin receptor-like kinase antibody, BMP type II receptor antibody, type II receptor for bone morphogenetic protein-4 antibody, BMP type-2 receptor antibody, BMPR-2 antibody, "bone morphogenetic protein receptor, type II (serine/threonine kinase) antibody"|
|Cellular Localization||Membrane |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human BMPR2. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Chicken, Sheep, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (91%), Pig (92%), Chicken (83%), Sheep (93%), Rhesus Monkey (98%), Bovine (93%)|