|Full Name||breast cancer 1, early onset|
|Product Description||Rabbit Polyclonal antibody to BRCA1 (breast cancer 1, early onset)|
|Background||This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified. [provided by RefSeq]|
|Synonyms||BRCAI antibody, BRCC1 antibody, BROVCA1 antibody, IRIS antibody, PNCA4 antibody, PSCP antibody, RNF53 antibody, BRCA1 antibody, breast cancer type 1 susceptibility protein antibody, RING finger protein 53 antibody, breast and ovarian cancer sususceptibility protein 1 antibody, breast and ovarian cancer susceptibility protein 1 antibody, "protein phosphatase 1, regulatory subunit 53 antibody", "BRCA1/BRCA2-containing complex, subunit 1 antibody", "breast cancer 1, early onset antibody"|
|Cellular Localization||Nucleus , Isoform 3: Cytoplasm , Isoform 5: Cytoplasm |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human BRCA1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rhesus Monkey, Chimpanzee|
|Predict Reactivity Note||Rhesus Monkey (100%), Chimpanzee (100%)|