|Full Name||breast cancer 2, early onset|
|Product Description||Rabbit Polyclonal antibody to BRCA2|
|Background||Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]|
|Synonyms||FANCB Antibody, FACD Antibody, FANCD1 Antibody, BRCC2 Antibody, GLM3 Antibody, BROVCA2 Antibody, FANCD Antibody, FAD1 Antibody, PNCA2 Antibody, FAD Antibody, breast cancer 2, early onset Antibody|
|Immunogen||KLH conjugated synthetic peptide derived from human BRCA2 (19-60aa)|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Bovine, Rabbit, Horse, Chicken, Dog|