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1 .GTX31248 BRCC36 antibody

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BRCC36 antibody


  • Host / ClonalityRabbit Polyclonal
  • ApplicationsIHC-P, WB
  • Species reactivityHuman, Mouse, Rat
Cat No: GTX31248
Package Price Qty
100 μgUSD 329.00
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  • Anti-BRCC36 antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX31248
  • Anti-BRCC36 antibody used in Western Blot (WB). GTX31248
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  • Datasheet
  • Application Information: BRCC36 antibody

Catalog Number GTX31248
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Product Name BRCC36 antibody
See all BRCC36 products
ApplicationsIHC-P, WB
Application Note
Suggested dilutionReference
IHC (Formalin-fixed paraffin-embedded sections)Assay-dependent dilution  
Western Blot (WB)0.5-1μg/ml*  
IHC (Formalin-fixed paraffin-embedded sections) : This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blot (WB) : This antibody detects a band of approximately 36kDa in MCF7 cell lysates.
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
Form SuppliedLiquid
Concentration1.0 mg/ml (Please refer to the vial label for the specific concentration)
PurificationPurified by affinity chromatography

  • Specifications: BRCC36 antibody

Full NameBRCA1/BRCA2-containing complex subunit 3
BackgroundThis gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
SynonymsBRCA1/BRCA2-containing complex, subunit 3 Antibody , CXorf53 Antibody , C6.1A Antibody , RP11-143H17.2 Antibody , BRCC3 Antibody
SpecificityThis antibody recognises human BRCA1/BRCA2 complex subunit 36 (BRCC36), a 36.7 kDa nuclear protein.
HostRabbit
ClonalityPolyclonal
IsotypeIgG
ImmunogenAn 18 amino acid peptide from near the amino terminus of human BRCC36.
Antigen SpeciesHuman
Species ReactivityHuman, Mouse, Rat
ConjugationUnconjugated

  • Storage Conditions: BRCC36 antibody

Storage BufferPBS, 0.02% Sodium Azide
Storage InstructionKeep as concentrated solution. For short-term storage, store at 4° C (up to 10 days). For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. This product may contain precipitation. Recommend microcentrifugation before use.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Cancer > Cell cycle > Intracellular and checkpoint control > G2-M
  • Cancer > DNA repair > Regulation > Positive regulation
  • Cancer > Tumor biomarkers
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BRCC36 antibody validated data
  • Anti-BRCC36 antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX31248
    • GTX31248 IHC-P Image
      IHC-P analysis of human brain tissue using GTX31248 BRCC36 antibody.
      Top
  • Anti-BRCC36 antibody used in Western Blot (WB). GTX31248
    • GTX31248 WB Image
      WB analysis of MCF-7 cell lysate using GTX31248 BRCC36 antibody at (A)0.5, (B)1 and (C)2 ug/ml.
      Top
  • Anti-BRCC36 antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX31248
    • GTX31248 IHC-P Image
      IHC-P analysis of human brain tissue using GTX31248 BRCC36 antibody.
      Top
  • Anti-BRCC36 antibody used in Western Blot (WB). GTX31248
    • GTX31248 WB Image
      WB analysis of MCF-7 cell lysate using GTX31248 BRCC36 antibody at (A)0.5, (B)1 and (C)2 ug/ml.
      Top
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All products are for research use only—Not for use in diagnostic procedures.