|Full Name||ATP-binding cassette, sub-family B (MDR/TAP), member 11|
|Product Description||Rabbit Polyclonal antibody to BSEP (ATP-binding cassette, sub-family B (MDR/TAP), member 11)|
|Background||The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq]|
|Synonyms||ABC16 antibody, BRIC2 antibody, BSEP antibody, PFIC-2 antibody, PFIC2 antibody, PGY4 antibody, SPGP antibody, ABCB11 antibody, ATP-binding cassette sub-family B member 11 antibody, sister p-glycoprotein antibody, bile salt export pump antibody, progressive familial intrahepatic cholestasis 2 antibody, ABC member 16, MDR/TAP subfamily antibody, ATP-binding cassette, sub-family B (MDR/TAP), member 11 antibody|
|Cellular Localization||Membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human BSEP. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Cat, Rabbit, Bovine, Guinea pig|
|Predict Reactivity Note||Mouse (85%), Rat (88%), Dog (85%), Cat (89%), Rabbit (84%), Bovine (89%), Guinea pig (82%)|