| Product Description | Mouse monoclonal [BAP0104] to Bacillus anthracis protective antigen |
| Background | Protective antigen (PA) is one of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax. Anthrax toxins are composed of three distinct proteins, a protective antigen (PA), a lethal factor (LF) and an edema factor (EF). None of these is toxic by itself. PA+LF forms the lethal toxin (LeTx); PA+EF forms the edema toxin (EdTx). PA-63 forms heptamers and this oligomerization is required for LF or EF binding. Once activated, at low pH, the heptamer undergoes conformational changes and converts from prepore to pore inserted in the membrane, forming cation-selective channels. |
| Synonyms | 2820165, Bacillus anthracis protective antigen, pagA |
| Specificity | This antibody is not cross-reacting with lethal factor antigen of B. antracis, Y.Pestis, F. Tularensis, and Toxoplasma gondii. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | BAP0104 |
| Target | Bacillus anthracis protective antigen |
| Isotype | IgG2b |
| Immunogen | Highly purified protective antigen of Bacillus anthracis. |