Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||18.9KDa (note)
|Positive Controls||A549 , H1299 , HCT116 , MCF-7 , PC-12 , Rat2|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||BCL2-like 1|
|Product Description||Rabbit Polyclonal antibody to Bcl-XS (BCL2-like 1)|
|Background||The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq]|
|Synonyms||BCL-XL/S antibody, BCL2L antibody, BCLX antibody, BCLXL antibody, BCLXS antibody, Bcl-X antibody, DKFZp781P2092 antibody, bcl-xL antibody, bcl-xS antibody, BCL2L1 antibody, apoptosis regulator Bcl-X antibody, bcl-2-like protein 1 antibody, "protein phosphatase 1, regulatory subunit 52 antibody", BCL2-like 1 antibody|
|Cellular Localization||Mitochondrion membrane; Single-pass membrane protein , Nucleus membrane; Single-pass membrane protein; Cytoplasmic side , Mitochondrion membrane , Nucleus membrane |
|Specificity||GTX124266 Bcl-XS antibody was designed specific for BCL-XS
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Bcl-XS. The exact sequence is proprietary.|
|Species Reactivity||Human, Rat|