|Full Name||breakpoint cluster region|
|Product Description||Rabbit Polyclonal antibody to Bcr (breakpoint cluster region)|
|Background||A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||ALL antibody, BCR1 antibody, CML antibody, D22S11 antibody, D22S662 antibody, FLJ16453 antibody, PHL antibody, BCR antibody, breakpoint cluster region protein antibody, renal carcinoma antigen NY-REN-26 antibody, breakpoint cluster region antibody|
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human Bcr. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Mouse (96%)|