|Full Name||BMI1 polycomb ring finger oncogene|
|Product Description||Rabbit Polyclonal antibody to Bmi1 (BMI1 polycomb ring finger oncogene)|
|Background||Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. |
|Synonyms||FLVI2/BMI1 Antibody, PCGF4 Antibody, BMI1 Antibody, BMI1 polycomb ring finger oncogene Antibody, RNF51 Antibody|
|Cellular Localization||Nucleus , Cytoplasm|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Bmi1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Xenopus laevis, Dog, Cat, Pig, Chicken, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (96%), Rat (92%), Xenopus laevis (82%), Dog (98%), Cat (99%), Pig (99%), Chicken (94%), Chimpanzee (100%), Bovine (98%)|