|Full Name||chromosome 14 open reading frame 169|
|Product Description||Goat polyclonal antibody to C14orf169 / NO66|
|Background||Histone demethylase that specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. |
|Synonyms||FLJ21802, C14orf169, MAPJD, chromosome14 open reading frame169, C14orf169 / NO66, NO66, chromosome 14 open reading frame 169|
|Cellular Localization||Granular part of nucleoli. Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli. |
|Specificity||This antibody is specific for C14orf169 / NO66.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.