|Full Name||spindle and kinetochore associated complex subunit 1|
|Product Description||Rabbit Polyclonal antibody to C18orf24 (spindle and kinetochore associated complex subunit 1)|
|Background||Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules. |
|Synonyms||C18orf24 antibody, MGC10200 antibody, SKA1 antibody, spindle and KT (kinetochore) associated 1 antibody, spindle and kinetochore-associated protein 1 antibody, spindle and kinetochore associated complex subunit 1 antibody|
|Cellular Localization||Spindle , Kinetochore |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human C18orf24. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rhesus Monkey (94%), Bovine (87%)|