|Full Name||BRISC and BRCA1 A complex member 1|
|Product Description||Mouse Monoclonal antibody to HSPC142 (BRISC and BRCA1 A complex member 1)|
|Background||Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component. |
|Synonyms||BRISC and BRCA1 A complex member 1 Antibody, BABAM1 Antibody, HSPC142 Antibody, NBA1 Antibody, MERIT40 Antibody|
|Cellular Localization||Cytoplasm , Nucleus |
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (82%), Rat (82%), Rhesus Monkey (97%), Bovine (90%)|