C5L2 antibody [C2C3], C-term
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||36 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||G protein-coupled receptor 77|
|Product Description||Rabbit polyclonal antibody to C5L2 (G protein-coupled receptor 77)|
|Background||The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005 [PubMed 16204243]).[supplied by OMIM]|
|Synonyms||C5L2 antibody, GPF77 antibody, GPR77 antibody, G-protein coupled receptor 77 antibody, C5a anaphylatoxin chemotactic receptor C5L2 antibody, G protein-coupled receptor C5L2 antibody, G protein-coupled receptor 77 antibody|
|Cellular Localization||Cell membrane |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human C5L2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Bovine (86%)|