|Full Name||caspase recruitment domain family, member 11|
|Product Description||Rabbit Polyclonal antibody to CARD11 (caspase recruitment domain family, member 11)|
|Background||The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq]|
|Synonyms||BIMP3 antibody, CARMA1 antibody, MGC133069 antibody, CARD11 antibody, CARD-containing MAGUK protein 1 antibody, card-maguk protein 1 antibody, caspase recruitment domain-containing protein 11 antibody, carma 1 antibody, bcl10-interacting maguk protein 3 antibody, caspase recruitment domain family, member 11 antibody|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human CARD11. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Chicken (87%), Bovine (98%)|