| Full Name | NLR family, CARD domain containing 4 |
| Product Description | Mouse Monoclonal antibody [GT1387] to CARD12 (NLR family, CARD domain containing 4) |
| Background | In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM] |
| Synonyms | CLAN1 Antibody , CLANB Antibody , CLANA Antibody , IPAF Antibody , CLAN Antibody , CLR2.1 Antibody , CLANC Antibody , NLR family, CARD domain containing 4 Antibody , CLAND Antibody , NLRC4 Antibody |
| Cellular Localization | Cytoplasm |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | GT1387 |
| Target | CARD12 |
| Isotype | IgG2a |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human CARD12. The exact sequence is proprietary. |
| Antigen Species | Human |
| Species Reactivity | Human |
Predicted Cross Reactivity species  Predicted cross-reactivity:
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
| Bovine |
| Predict Reactivity Note | Bovine (82%) |
| Conjugation | Unconjugated |