|Full Name||NLR family, CARD domain containing 4|
|Product Description||Mouse Monoclonal antibody [GT1387] to CARD12 (NLR family, CARD domain containing 4)|
|Background||In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM]|
|Synonyms||CLAN1 Antibody , CLANB Antibody , CLANA Antibody , IPAF Antibody , CLAN Antibody , CLR2.1 Antibody , CLANC Antibody , NLR family, CARD domain containing 4 Antibody , CLAND Antibody , NLRC4 Antibody|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human CARD12. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Bovine (82%)|