|Full Name||Cas-Br-M (murine) ecotropic retroviral transforming sequence|
|Product Description||Rabbit Polyclonal antibody to CBL (Cas-Br-M (murine) ecotropic retroviral transforming sequence)|
|Background||The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq]|
|Synonyms||C-CBL antibody, CBL2 antibody, RNF55 antibody, CBL antibody, casitas B-lineage lymphoma proto-oncogene antibody, E3 ubiquitin-protein ligase CBL antibody, signal transduction protein CBL antibody, proto-oncogene c-Cbl antibody, oncogene CBL2 antibody, RING finger protein 55 antibody, Cas-Br-M (murine) ecotropic retroviral transforming sequence antibody|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human CBL. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rhesus Monkey|
|Predict Reactivity Note||Mouse (84%), Rhesus Monkey (95%)|