|Full Name||cell division cycle and apoptosis regulator 1|
|Product Description||Rabbit Polyclonal antibody to CCAR1 (cell division cycle and apoptosis regulator 1)|
|Background||Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. |
|Synonyms||RP11-437A18.1 Antibody, cell division cycle and apoptosis regulator 1 Antibody|
|Cellular Localization||Cytoplasm , perinuclear region |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CCAR1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Xenopus laevis, Xenopus Tropicalis, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (97%), Xenopus laevis (82%), Xenopus Tropicalis (84%), Rhesus Monkey (100%), Bovine (99%)|