|Full Name||cerebral cavernous malformation 2|
|Product Description||Rabbit polyclonal antibody to CCM2 (cerebral cavernous malformation 2)|
|Background||This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.|
|Synonyms||C7orf22 antibody, MGC4067 antibody, MGC4607 antibody, MGC74868 antibody, OSM antibody, CCM2 antibody, cerebral cavernous malformations 2 protein antibody, malcavernin antibody, cerebral cavernous malformation 2 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CCM2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (92%), Rat (91%), Chicken (84%), Rhesus Monkey (100%), Bovine (93%)|