|Full Name||chemokine (C-C motif) receptor 3|
|Product Description||Rabbit Polyclonal antibody to CCR3 (chemokine (C-C motif) receptor 3)|
|Background||The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq]|
|Synonyms||CC-CKR-3 antibody, CD193 antibody, CKR3 antibody, CMKBR3 antibody, MGC102841 antibody, CCR3 antibody, C-C CKR-3 antibody, C-C chemokine receptor type 3 antibody, eosinophil eotaxin receptor antibody, CC chemokine receptor 3 antibody, CCR-3 antibody, eosinophil CC chemokine receptor 3 antibody, b-chemokine receptor antibody, chemokine (C-C motif) receptor 3 antibody|
|Cellular Localization||Cell membrane |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human CCR3. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rhesus Monkey (93%)|