|Full Name||chemokine (C-C motif) receptor 5 (gene/pseudogene)|
|Product Description||Rabbit Polyclonal antibody to CCR5 (chemokine (C-C motif) receptor 5 (gene/pseudogene))|
|Background||This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]|
|Synonyms||chemokine (C-C motif) receptor 5 (gene/pseudogene) Antibody , CD195 Antibody , CKR5 Antibody , CCCKR5 Antibody , CC-CKR-5 Antibody , CMKBR5 Antibody , IDDM22 Antibody , CKR-5 Antibody , CCR-5 Antibody|
|Cellular Localization||Cell membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CCR5. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Cat, Pig, Rabbit, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (87%), Rat (87%), Dog (85%), Cat (83%), Pig (86%), Rabbit (82%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (86%)|