|Full Name||membrane metallo-endopeptidase|
|Product Description||Rabbit Polyclonal antibody to CD10 (membrane metallo-endopeptidase)|
|Background||This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq]|
|Synonyms||CALLA antibody, CD10 antibody, DKFZp686O16152 antibody, MGC126681 antibody, MGC126707 antibody, NEP antibody, SFE antibody, MME antibody, membrane metallo-endopeptidase variant 2 antibody, neprilysin antibody, atriopeptidase antibody, enkephalinase antibody, membrane metallo-endopeptidase variant 1 antibody, membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase) antibody, skin fibroblast elastase antibody, neutral endopeptidase 24.11 antibody, membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) antibody, common acute lymphocytic leukemia antigen antibody, membrane metallo-endopeptidase antibody|
|Cellular Localization||Cell membrane; Single-pass type II membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CD10. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Dog, Rabbit, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Dog (89%), Rabbit (88%), Rhesus Monkey (98%), Bovine (86%)|