| Full Name | integrin subunit alpha L |
| Background | ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Synonyms | LFA1 Antibody , CD11A Antibody , LFA1A Antibody , ITGAL Antibody |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_002200.2; NP_001107852.1). |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Peptide with sequence C-YQVRIQPSIHDHN, from the internal region of the protein sequence according to NP_002200.2; NP_001107852.1. |
| Antigen Species | Human |
| Species Reactivity | Human |
| Conjugation | Unconjugated |