|Full Name||integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)|
|Product Description||Rabbit Polyclonal antibody to CD11a (integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide))|
|Background||ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||CD11A antibody, LFA-1 antibody, LFA1A antibody, ITGAL antibody, CD11 antigen-like family member A antibody, integrin gene promoter antibody, integrin alpha-L antibody, leukocyte function-associated molecule 1 alpha chain antibody, lymphocyte function-associated antigen 1 antibody, LFA-1 alpha antibody, "antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide antibody", LFA-1A antibody, leukocyte adhesion glycoprotein LFA-1 alpha chain antibody, "integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide) antibody"|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human CD11a. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Chimpanzee (82%)|