|Full Name||interleukin 6 signal transducer (gp130, oncostatin M receptor)|
|Product Description||Rabbit Polyclonal antibody to CD130 (interleukin 6 signal transducer (gp130, oncostatin M receptor))|
|Background||The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]|
|Synonyms||CD130 antibody, CDW130 antibody, DKFZp564F053 antibody, GP130 antibody, IL-6RB antibody, IL6ST antibody, membrane glycoprotein gp130 antibody, IL-6R subunit beta antibody, CD130 antigen antibody, interleukin-6 receptor subunit beta antibody, oncostatin-M receptor subunit alpha antibody, membrane glycoprotein 130 antibody, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form antibody, IL-6 receptor subunit beta antibody, interleukin receptor beta chain antibody, interleukin 6 signal transducer (gp130, oncostatin M receptor) antibody|
|Cellular Localization||Isoform 1: Cell membrane; Single-pass type I membrane protein , Isoform 2: Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human CD130. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Pig, Rhesus Monkey|
|Predict Reactivity Note||Mouse (91%), Rat (92%), Dog (94%), Pig (95%), Rhesus Monkey (98%)|