|Full Name||melanoma cell adhesion molecule|
|Product Description||Rabbit Polyclonal antibody to CD146 (melanoma cell adhesion molecule)|
|Background||Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.|
|Synonyms||CD146 antibody, MUC18 antibody, MCAM antibody, melanoma adhesion molecule antibody, Gicerin antibody, melanoma-associated antigen A32 antibody, cell surface glycoprotein MUC18 antibody, cell surface glycoprotein P1H12 antibody, S-endo 1 endothelial-associated antigen antibody, melanoma-associated antigen MUC18 antibody, melanoma cell adhesion molecule antibody|
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human CD146. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Bovine (81%)|