|Full Name||CD1a molecule|
|Product Description||APC-conjugated Mouse Monoclonal antibody [HI149] to CD1a|
|Background||CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.Entrez Gene: 1q22-q23|
|Cellular Localization||Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts. |
|Specificity||The antibody HI149 reacts with CD1a (T6), a 49 KDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas. |
The antibody does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes.