|Full Name||dipeptidyl-peptidase 4|
|Product Description||Goat Polyclonal antibody to CD26|
|Background||Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. |
|Synonyms||adenosine deaminase complexing protein2, dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing prote, dipeptidylpeptidase IV, Tcell activation antigen CD26, adenosine deaminase complexing protein 2, TP103, dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2), DPPIV, dipeptidylpeptidase4 (CD26, adenosine deaminase complexing prote, dipeptidylpeptidase4 (CD26, adenosine deaminase complexing protein2), DPP4 / CD26, ADABP, ADCP2, CD26|
|Cellular Localization||Detected in the serum and the seminal fluid. Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids. Redistributed to membrane rafts in T-ce|
|Specificity||This antibody is specific for DPP4 / CD26.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Dog|