|Full Name||CD40 molecule, TNF receptor superfamily member 5|
|Product Description||Rabbit Polyclonal antibody to CD40 (CD40 molecule, TNF receptor superfamily member 5)|
|Background||The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]|
|Synonyms||Bp50 antibody, CDW40 antibody, MGC9013 antibody, TNFRSF5 antibody, p50 antibody, CD40 antibody, CD40L receptor antibody, CD40 antigen (TNF receptor superfamily member 5) antibody, B cell-associated molecule antibody, CD40 type II isoform antibody, B-cell surface antigen CD40 antibody, tumor necrosis factor receptor superfamily member 5 antibody, B cell surface antigen CD40 antibody, "tumor necrosis factor receptor superfamily, member 5 antibody", nerve growth factor receptor-related B-lymphocyte activation molecule antibody, "CD40 molecule, TNF receptor superfamily member 5 antibody"|
|Cellular Localization||Isoform I: Cell membrane; Single-pass type I membrane protein , Isoform II: Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CD40. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rhesus Monkey (93%)|