| Full Name | CD40 ligand |
| Product Description | Mouse monoclonal [5F3] to CD40L |
| Background | CD40 ligand (CD40L), also known as CD154, gp39 and TRAP, is a 33 kDa type II membrane glycoprotein expressed mainly on the cell surface of activated T lymphocytes, but also exists as a soluble form extracellularly. CD40L is the ligand for CD40, a member of the TNF superfamily, which is expressed on the cell surface of B cells, macrophages/monocytes, dendritic cells, vascular endothelial cells, and epithelial cells. CD40L plays an important role in B cell proliferation, antibody class switching, modulation of apoptosis in the germinal center through interaction with B cells expressing CD40, and activation of CD4+ T cells. Mutation within the CD40L gene is linked to hyper IgM syndrome, an X-linked immunodeficiency disease that is characterized by elevated level of serum IgM and decreased level of other isotypes. |
| Synonyms | TRAP, IMD3, CD40L, 300386, 959, IGM, TNFSF5, HIGM1, CD40LG, CD154, gp39, TBAM, hCD40L, P29965, T-BAM, T BAM |
| Cellular Localization | Type II membrane protein. Also exists as an extracellular soluble form. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | 5F3 |
| Target | CD40L |
| Isotype | IgG1 |
| Immunogen | Human CD40L (CD154) transfected 300-19 cell (Mouse pre-B cell line). |
| Antigen Species | Human |
| Species Reactivity | Human |