|Full Name||integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)|
|Product Description||Rabbit Polyclonal antibody to CD41|
|Background||ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq]|
|Synonyms||CD41 antibody, CD41B antibody, GP2B antibody, GPIIb antibody, GTA antibody, HPA3 antibody, ITGA2B antibody, platelet membrane glycoprotein IIb antibody, GPalpha IIb antibody, integrin alpha-IIb antibody, platelet fibrinogen receptor, alpha subunit antibody, platelet-specific antigen BAK antibody, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) antibody|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CD41. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Dog, Pig, Rabbit, Bovine|
|Predict Reactivity Note||Dog (88%), Pig (82%), Rabbit (87%), Bovine (86%)|