CD42b antibody [AK2] (Low endotoxin, azide free)
|Applications||ELISA, FACS, IP, Functional Assay|
| ELISA||Assay-dependent dilution
| Immunoprecipitation||Assay-dependent dilution
| Functional Assay||Assay-dependent dilution
Flow cytometry/FACS : Use 10μl of the suggested working dilution to label 106 cells or 100μl whole blood.Not tested in other applications.
Functional Assay : This antibody has been reported to block the binding of von Willebrand Factor (VWF) to platelets.
*Optimal dilutions/concentrations should be determined by the researcher.
(Please refer to the vial label for the specific concentration)|
|Purification||Protein G purified|
|Purification Note||From tissue culture supernatant|
|Full Name||glycoprotein Ib platelet alpha subunit|
|Product Description||Mouse monoclonal antibody [AK2] to CD42b|
|Background||Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013]|
|Synonyms||DBPLT3 Antibody , GPIBA Antibody , CD42B Antibody , CD42B-ALPHA Antibody , GP1B Antibody , GP1BA Antibody , VWDP Antibody , BSS Antibody , BDPLT3 Antibody , BDPLT1 Antibody|