|Full Name||glycoprotein Ib (platelet), beta polypeptide|
|Product Description||Rabbit polyclonal antibody to CD42c (glycoprotein Ib (platelet), beta polypeptide)|
|Background||Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal within a separate gene (septin 5) located upstream of this gene. In the absence of polyadenylation from its own imperfect site, the septin 5 gene uses the consensus polyA signal of this gene. [provided by RefSeq]|
|Synonyms||CD42C antibody, GPIBB antibody, GP1BB antibody, nuclear localization signal deleted in velocardiofacial syndrome antibody, GP-Ib beta antibody, antigen CD42b-beta antibody, platelet glycoprotein Ib beta chain antibody, GPIb-beta antibody, "glycoprotein Ib (platelet), beta polypeptide antibody"|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human CD42c. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Mouse (100%)|