|Full Name||CD59 molecule, complement regulatory protein|
|Product Description||Rabbit Polyclonal antibody to CD59 (CD59 molecule, complement regulatory protein)|
|Background||This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq]|
|Synonyms||MEM43 Antibody , MIC11 Antibody , EJ30 Antibody , p18-20 Antibody , MIN2 Antibody , MSK21 Antibody , 16.3A5 Antibody , MAC-IP Antibody , HRF-20 Antibody , EL32 Antibody , MACIF Antibody , MIN1 Antibody , 1F5 Antibody , CD59 molecule, complement regulatory protein Antibody , EJ16 Antibody , MIRL Antibody , MIN3 Antibody , G344 Antibody , HRF20 Antibody|
|Cellular Localization||Cell membrane , GPI-anchor , Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CD59. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Chimpanzee (96%)|