| Full Name | transferrin receptor (p90, CD71) |
| Background | Cellular uptake of iron occurs via receptor mediated endocytosis of ligand occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Useful in studies of dividing haematopoietic and tumour cell populations, and metabolic activity. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C terminal binding site. The antigen is present on most dividing cells, including normally cycling in vivo hematopoietic progenitor cells, mitogenically stimulated cells in vitro, some primary tumor cells and most proliferating cells in vitro.The transferrin receptor has been structurally characterized as a sulfide-bound dimer of identical glycoprotein subunits of 95 kD. The transferrin receptor is not present on resting blood lymphocytes. On PBL, the receptor appears after activation. The expression of transferrin receptor is coordinately regulated with cell growth. Present on T and B cell lines. |
| Synonyms | TFR, TFR1, 7037, 190010, Transferrin receptor, TFRC, CD71, P02786, TRFR |
| Cellular Localization | Type II membrane protein. Secreted. |
| Specificity | CD71 antigen (transferrin receptor). This antibody does not block binding of transferrin to the receptor. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | MEM-75 |
| Isotype | IgG1 |
| Immunogen | Pre-B cell line NALM-6 (Human). |
| Antigen Species | Human |
| Species Reactivity | Human |
| Conjugation | Phycoerythrin (PE) |