|Full Name||5'-nucleotidase, ecto (CD73)|
|Product Description||Rabbit Polyclonal antibody to CD73 (5'-nucleotidase, ecto (CD73))|
|Background||Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 184.108.40.206) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.[supplied by OMIM]|
|Synonyms||CD73 antibody, E5NT antibody, NT antibody, NT5 antibody, NTE antibody, eN antibody, eNT antibody, NT5E antibody, 5'-NT antibody, Purine 5-Prime-Nucleotidase antibody, 5'-nucleotidase antibody, ecto-5'-nucleotidase antibody, "5'-nucleotidase, ecto (CD73) antibody"|
|Cellular Localization||Cell membrane , GPI-anchor |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CD73. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (91%), Bovine (93%)|