| Full Name | Fc fragment of IgA, receptor for |
| Background | This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] |
| Synonyms | CD89 antibody, FCAR antibody, immunoglobulin alpha Fc receptor antibody, Fc alpha receptor antibody, IgA Fc receptor antibody, "Fc fragment of IgA, receptor for antibody" |
| Cellular Localization | Isoform A , 1: Cell membrane; Single-pass type I membrane protein , 2: Cell membrane; Single-pass type I membrane protein , 3: Cell membrane; Single-pass type I membrane protein , Isoform B: Secreted , Isoform B-delta-S2: Secreted |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human CD89. The exact sequence is proprietary. |
| Antigen Species | Human |
| Species Reactivity | Human |
Predicted Cross Reactivity species  Predicted cross-reactivity:
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
| Rhesus Monkey, Chimpanzee |
| Predict Reactivity Note | Rhesus Monkey (92%), Chimpanzee (93%) |
| Conjugation | Unconjugated |