|Full Name||Fc fragment of IgA, receptor for|
|Product Description||Rabbit Polyclonal antibody to CD89 (Fc fragment of IgA, receptor for)|
|Background||This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]|
|Synonyms||CD89 antibody, FCAR antibody, immunoglobulin alpha Fc receptor antibody, Fc alpha receptor antibody, IgA Fc receptor antibody, "Fc fragment of IgA, receptor for antibody"|
|Cellular Localization||Isoform A , 1: Cell membrane; Single-pass type I membrane protein , 2: Cell membrane; Single-pass type I membrane protein , 3: Cell membrane; Single-pass type I membrane protein , Isoform B: Secreted , Isoform B-delta-S2: Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CD89. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rhesus Monkey, Chimpanzee|
|Predict Reactivity Note||Rhesus Monkey (92%), Chimpanzee (93%)|