| Full Name | CD8b molecule |
| Background | The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010] |
| Synonyms | CD8B1 Antibody , LYT3 Antibody , CD8B Antibody , LEU2 Antibody , LY3 Antibody , P37 Antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | A synthetic peptide corresponding to an Internal region of Human CD8B |
| Antigen Species | Human |
| Species Reactivity | Human |
| Predict Reactivity Note | Dog: 79%; Human: 100%; Rabbit: 93%; Rat: 85% |
| Conjugation | Unconjugated |