|Full Name||cell division cycle 42 (GTP binding protein, 25kDa)|
|Product Description||Rabbit polyclonal antibody to CDC42 (cell division cycle 42 (GTP binding protein, 25kDa))|
|Background||The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]|
|Synonyms||CDC42Hs antibody, G25K antibody, CDC42 antibody, cell division control protein 42 homolog antibody, "dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)) antibody", small GTP binding protein CDC42 antibody, "dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)) antibody", "GTP-binding protein, 25kD antibody", G25K GTP-binding protein antibody, growth-regulating protein antibody, "cell division cycle 42 (GTP binding protein, 25kDa) antibody"|
|Cellular Localization||Cell membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CDC42. The exact sequence is proprietary.|
|Species Reactivity||Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Zebrafish, Drosophila, Xenopus laevis, Dog, Pig, Chicken, Sheep, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Human (100%), Zebrafish (99%), Drosophila (92%), Xenopus laevis (99%), Dog (100%), Pig (95%), Chicken (99%), Sheep (99%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%)|