|Full Name||fizzy/cell division cycle 20 related 1 (Drosophila)|
|Product Description||Rabbit Polyclonal antibody to FZR1 (fizzy/cell division cycle 20 related 1 (Drosophila))|
|Background||Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. |
|Synonyms||CDC20C antibody, CDH1 antibody, FZR antibody, FZR2 antibody, HCDH antibody, HCDH1 antibody, KIAA1242 antibody, FZR1 antibody, CDC20-like 1b antibody, fizzy-related protein homolog antibody, CDC20-like protein 1 antibody, cdh1/Hct1 homolog antibody, fizzy/cell division cycle 20 related 1 (Drosophila) antibody|
|Cellular Localization||Isoform 2: Nucleus , Isoform 3: Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human FZR1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Xenopus laevis, Pig, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Xenopus laevis (90%), Pig (97%), Chicken (94%), Rhesus Monkey (100%), Bovine (97%)|