|Full Name||cyclin-dependent kinase 4|
|Product Description||Rabbit Polyclonal antibody to CDK4 (cyclin-dependent kinase 4)|
|Background||The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq]|
|Synonyms||CMM3 antibody, MGC14458 antibody, PSK-J3 antibody, CDK4 antibody, cell division protein kinase 4 antibody, cyclin-dependent kinase 4 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CDK4. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Sheep, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (94%), Pig (98%), Sheep (95%), Rhesus Monkey (100%), Bovine (95%)|