|Full Name||cyclin-dependent kinase 8|
|Product Description||Rabbit polyclonal antibody to CDK8 (cyclin-dependent kinase 8)|
|Background||The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq]|
|Synonyms||K35 antibody, MGC126074 antibody, MGC126075 antibody, CDK8 antibody, CDK8 protein kinase antibody, mediator of RNA polymerase II transcription subunit CDK8 antibody, mediator complex subunit CDK8 antibody, cyclin-dependent kinase 8 antibody, protein kinase K35 antibody, cell division protein kinase 8 antibody|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human CDK8. The exact sequence is proprietary.|
|Species Reactivity||human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Rat, Zebrafish, Xenopus laevis, Rhesus Monkey|
|Predict Reactivity Note||Human (100%), Rat (100%), Zebrafish (100%), Xenopus laevis (100%), Rhesus Monkey (100%)|