|Full Name||denticleless homolog (Drosophila)|
|Product Description||Rabbit Polyclonal antibody to CDT2 (denticleless homolog (Drosophila))|
|Background||Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.|
|Synonyms||CDT2 antibody, DCAF2 antibody, L2DTL antibody, RAMP antibody, DTL antibody, DDB1 and CUL4 associated factor 2 antibody, denticleless protein homolog antibody, RA-regulated nuclear matrix-associated protein antibody, DDB1- and CUL4-associated factor 2 antibody, RA regulated nuclear matrix associated protein antibody, lethal(2) denticleless protein homolog antibody, retinoic acid-regulated nuclear matrix-associated protein antibody, denticleless homolog (Drosophila) antibody|
|Cellular Localization||Nucleus membrane , Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human CDT2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rhesus Monkey|
|Predict Reactivity Note||Human (100%), Mouse (88%), Rhesus Monkey (99%)|