| Full Name | CCAAT/enhancer binding protein (C/EBP), alpha |
| Background | The C/EBP (CCAAT/enhancer binding protein) family of transcription factors--alpha, beta, delta, and epsilon)--are widely expressed proteins found in a variety of tissues.? These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L) KXEP.? One of the major roles of these transcription factors is that of metabolic regulation in liver and fat cells.? Studies suggest that these transcription factors act in a cascade aiding in the development of the adipose cell. Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different function in gene regulation.? From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in AD patients. |
| Synonyms | CEBP, P49715, C/EBPalpha, 1050, 116897, DBPCEP, Cebpa, C/EBP-alpha, 24252, C/EBP alpha |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein corresponding to residues 466-813 of rat C/EBP alpha. |
| Antigen Species | Mouse |
| Species Reactivity | Human, Mouse |
| Conjugation | Unconjugated |