|Full Name||checkpoint with forkhead and ring finger domains|
|Product Description||Rabbit Polyclonal antibody to CHFR (checkpoint with forkhead and ring finger domains)|
|Background||E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.|
|Synonyms||FLJ10796 antibody, FLJ33629 antibody, RNF116 antibody, RNF196 antibody, CHFR antibody, checkpoint with forkhead and RING finger domains protein antibody, E3 ubiquitin-protein ligase CHFR antibody, RING finger protein 196 antibody, checkpoint with forkhead and ring finger domains antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CHFR. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (86%), Rat (85%), Bovine (81%)|