|Full Name||chromatin modifying protein 2B|
|Product Description||Rabbit Polyclonal antibody to CHMP2B (charged multivesicular body protein 2b)|
|Background||This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq]|
|Synonyms||CHMP2.5 antibody, DKFZp564O123 antibody, DMT1 antibody, VPS2-2 antibody, VPS2B antibody, CHMP2B antibody, chromatin modifying protein 2B antibody, vacuolar protein-sorting-associated protein 2-2 antibody, VPS2 homolog B antibody, charged multivesicular body protein 2b antibody|
|Cellular Localization||Cytoplasm , cytosol , Late endosome membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CHMP2B. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Xenopus laevis, Pig, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (100%), Xenopus laevis (94%), Pig (99%), Chicken (96%), Rhesus Monkey (99%), Bovine (99%)|