CHMP5 antibody [N1C3]
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||25 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji , mouse stomach|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||chromatin modifying protein 5|
|Product Description||Rabbit Polyclonal antibody to CHMP5 (chromatin modifying protein 5)|
|Background||CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM]|
|Synonyms||C9orf83 antibody, HSPC177 antibody, PNAS-2 antibody, SNF7DC2 antibody, Vps60 antibody, CHMP5 antibody, SNF7 domain containing 2 antibody, SNF7 domain-containing protein 2 antibody, chromatin-modifying protein 5 antibody, chromatin modifying protein 5 antibody, vacuolar protein sorting-associated protein 60 antibody, apoptosis-related protein PNAS-2 antibody, hVps60 antibody, charged multivesicular body protein 5 antibody|
|Cellular Localization||Cytoplasm , cytosol , Endosome membrane; Peripheral membrane protein , Cytoplasm , cytosol , Endosome membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CHMP5. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Xenopus laevis, Pig, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (98%), Xenopus laevis (88%), Pig (100%), Chicken (94%), Rhesus Monkey (100%), Bovine (100%)|