|Full Name||cartilage intermediate layer protein, nucleotide pyrophosphohydrolase|
|Product Description||Rabbit Polyclonal antibody to CILP (cartilage intermediate layer protein, nucleotide pyrophosphohydrolase)|
|Background||Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase, however later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. One isoform of the protein, CILP-1, functions as an IGF-1 antagonist. [provided by RefSeq]|
|Synonyms||CILP-1 antibody, HsT18872 antibody, CILP antibody, cartilage intermediate layer protein 1 C1 antibody, cartilage intermediate-layer protein antibody, cartilage intermediate layer protein 1 antibody, cartilage intermediate layer protein 1 C2 antibody, "cartilage intermediate layer protein, nucleotide pyrophosphohydrolase antibody"|
|Cellular Localization||Secreted , extracellular space , extracellular matrix |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human CILP. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Zebrafish, Pig|
|Predict Reactivity Note||Human (99%), Mouse (97%), Rat (97%), Zebrafish (85%), Pig (97%)|