|Full Name||cartilage intermediate layer protein, nucleotide pyrophosphohydrolase|
|Product Description||Goat polyclonal antibody to CILP|
|Background||Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. |
|Synonyms||cartilage intermediate layer protein, HsT18872, HGNC:1980, cartilage intermediate layer protein, nucleotide pyrophosphohydrolase, CILP, CILP-1, CILP 1, CILP1|
|Specificity||This antibody is specific for CILP.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Dog|